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1 de may. de 2014 · In this review, we discuss the characteristics of 3D cell culture systems in comparison to the two-dimensional (2D) monolayer culture, focusing on cell growth conditions, cell proliferation, population, and gene and protein expression profiles.
A 3D cell culture is an artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. Unlike 2D environments (e.g. a Petri dish), a 3D cell culture allows cells in vitro to grow in all directions, similar to how they would in vivo.
3D cell cultures are increasingly being used for basic research and drug discovery. Here you'll learn what 3D cell cultures are, why and how they are being used, and how to validate assays that work with 3D models.
12 de dic. de 2019 · Three-dimensional (3D) culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures. In cancer and stem cell research, the natural cell characteristics and architectures are closely mimicked by the 3D cell models.
4 de abr. de 2024 · We examine standardization, scalability and automation strategies, and outline high-throughput data generation and analysis approaches to interpret readouts of microfluidic 3D cell culture...
11 de oct. de 2021 · Compared to two-dimensional culture, three-dimensional culture system is better to realistically simulate the local microenvironment of cells, promote the exchange of information among cells and the extracellular matrix (ECM), and retain the original biological characteristics of stem cells.
21 de jun. de 2017 · 3D cell culture is an invaluable tool in developmental, cell, and cancer biology. By mimicking crucial features of in vivo environment, including cell–cell and cell–extracellular matrix interactions, 3D cell culture enables proper structural architecture and differentiated function of normal tissues or tumors in vitro.
