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17 de may. de 2017 · Protein kinase G (PknG) is known to be required for virulence of M. tuberculosis and is the only bacterial serine/threonine protein kinase to be known as a virulence factor. However, the molecular mechanisms underlying its function in virulence are unknown and the role (s) of PknG are controversial.
2 de may. de 2021 · Upon Mycobacterium tuberculosis (Mtb) infection, protein kinase G (PknG), a eukaryotic‐type serine‐threonine protein kinase (STPK), is secreted into host macrophages to promote intracellular survival of the pathogen. However, the mechanisms underlying this PknG–host interaction remain unclear. Here, we demonstrate that PknG ...
25 de abr. de 2019 · We summarize the mechanistic evidence that links PknB to the regulation of peptidoglycan synthesis in cell division and morphogenesis, and the major findings that establish PknG as a master ...
29 de sept. de 2017 · Protein kinase G (PknG), a thioredoxin-fold-containing eukaryotic-like serine/threonine protein kinase, is a virulence factor in Mycobacterium tuberculosis, required for inhibition of phagolysosomal fusion. Here, we unraveled novel functional facets of PknG during latency-like conditions.
6 de nov. de 2020 · Mtb PknG is a protein kinase that promotes ubiquitination and degradation of TRAF2 and TAK1, key components of NF-κB signaling. PknG uses an unusual isopeptide bond to attach and discharge ubiquitin from UbcH7, a ubiquitin-conjugating enzyme.
21 de mar. de 2024 · One of the essential components of M. tuberculosis survival and virulence is the serine-threonine protein kinase, PknG. This kinase regulates cell wall biosynthesis and cell division, making it...
2 de jun. de 2015 · PknG is a multidomain enzyme that controls central metabolism and pathogenicity in Mycobacterium tuberculosis. This article reports the biochemical and structural studies of PknG, revealing its substrate selectivity, kinase activity, and regulation by metal binding and dimerization.
