Resultado de búsqueda
14 de ene. de 2022 · We distilled this two-decade Pace of Aging into a single-time-point DNA-methylation blood-test using elastic-net regression and a DNA-methylation dataset restricted to exclude probes with low test-retest reliability. We evaluated the resulting measure, named DunedinPACE, in five additional datasets.
14 de ene. de 2022 · The new Dunedin Pace of Aging methylation algorithm (DunedinPACE) was developed using elastic-net regression analysis carried out in the Dunedin Study, as described in detail in the Results. The criterion variable was 20-year Pace of Aging.
14 de ene. de 2022 · We measured pace of biological aging using the DunedinPoAm DNA methylation algorithm, developed to quantify the pace-of-aging-related decline in system integrity.
30 de ago. de 2021 · We used data from the Dunedin Study 1972-3 birth cohort tracking within-individual decline in 19 indicators of organ-system integrity across four time points spanning two decades to model Pace of Aging. We distilled this two-decade Pace of Aging into a single-time-point DNA-methylation blood-test using elastic-net
9 de feb. de 2023 · Using samples and data from the CALERIE study, a human randomized controlled trial of long-term caloric restriction, the authors find that the intervention slows DunedinPACE, a DNA methylation ...
The new Dunedin Pace of Aging methylation algorithm (DunedinPACE) was developed using elastic-net regression analysis carried out in the Dunedin Study, as described in detail in the Results. The criterion variable was 20-year Pace of Aging.
26 de nov. de 2021 · A next-generation DNA-methylation biomarker of Pace of Aging, DunedinPACE, is reported, which showed high test-retest reliability, was associated with morbidity, disability, and mortality, and indicated faster aging in young adults with childhood adversity.
