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12 de dic. de 2023 · Daratumumab, a monoclonal antibody targeting CD38, has been approved for use with standard myeloma regimens. An evaluation of subcutaneous daratumumab combined with bortezomib, lenalidomide, and...
7 de mar. de 2024 · El daratumumab es un medicamento dirigido que elimina las células del mieloma múltiple y también recluta células inmunitarias para que ayuden a destruir las células cancerosas. Se administra mediante infusión intravenosa o mediante una inyección subcutánea (debajo de la piel).
25 de ago. de 2016 · Daratumumab, a human IgGκ monoclonal antibody that targets CD38, induces direct and indirect antimyeloma activity and has shown substantial efficacy as monotherapy in heavily pretreated patients...
Enfermedad pulmonar o respiratoria, tales como asma, EPOC. Una reacción alérgica o inusual al daratumumab, al sorbitol, a otros medicamentos, alimentos, colorantes o conservantes. Este medicamento se inyecta en una vena. Su equipo de atención lo administra en un hospital o en un entorno clínico.
17 de feb. de 2021 · The human monoclonal antibody anti-PD-L1 durvalumab, already adopted in lung neoplasm, is currently being tested in MEDI4736-MM-003, a safety and efficacy trial of daratumumab IV when administered in combination with daratumumab (DD) for the treatment of RRMM (65).
26 de ago. de 2020 · CD38 is a transmembrane glycoprotein with ectoenzymatic functions located predominately at the surface of plasma cells, making it a good target for novel therapeutic strategies. 12 CD38 is expressed on all clonal plasma cells regardless of the spectrum of disease (ex. MGUS, SMM, active MM).
29 de may. de 2019 · Daratumumab, a human IgGκ monoclonal antibody that targets CD38, has direct antitumor and immunomodulatory activity. 6-10 Initial approval of daratumumab as monotherapy for patients with heavily...
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